Building on science and innovation

Microbial actives by Biocare Copenhagen

Pioneering microbial actives bioscience

Our nutritional science competence is what enables us to innovate and support product development of dietary supplements with microbial actives.

As part of DSM, we have over 20 years of experience in performing clinical trials what makes research key to our product offerings. We are engaged into international multidisciplinary collaborations across the globe to perform clinical trials and post marketing studies to help to build knowledge around our product concepts. 

In this way, we build on our legacy. Biocare Copenhagen started as a technology-spin off from Danish Hospitals based on unique and exclusive probiotics strains. Today, we focus our science and innovation not only on these exclusive strains, but also on microbial actives in general. To further power our offering, we can combine microbial actives with a rich portfolio of proprietary DSM ingredients that are highly active to improve human health.

Strains best in test

Lactobacillus rhamnosus (FloraActive) 19070-2 (DSM 26357) and Lactobacillus reuteri (FloraActive) DSM 12246 (CBS 145621) are propriary strains of Biocare Copenhagen. Both strains come out of a large and comprehensive screening program performed at Danish hospitals in 1999 with the aim to identify probiotics with superior growth, pH tolerance, adhesion, and antimicrobial properties. Among 47 strains tested, Lactobacillus rhamnosus (FloraActive) 19070-2 as well as Lactobacillus reuteri (FloraActive) DSM 12246 belonged to the best performing strains.9

The species L. rhamnosus and L. reuteri are among the most important probiotic strains and there are hundreds of clinical studies relating to benefits for digestion and immunity. Intake of Lactobacillus rhamnosus (FloraActive) 19070-2 and Lactobacillus reuteri (FloraActive) DSM 12246 has been show in clinical studies to be beneficial in rotavirus and Clostridium difficile-associated gastroenteritis and was associated with reduced diarrhea prevalence and duration in hospitalized and non-hospitalized patients.6,7 In addition, clinical studies show that both strains are linked to decreased frequency of gastrointestinal symptoms and eczema as well as improved intestinal barrier function in children with atopic dermatitis.4,5 Finally, both strains were associated with a decrease in cry and fuss time indicating benefits as a dietary support in infants with colic.2 As part of a multi-strain synbiotic preparation, Lactobacillus rhamnosus FloraActive 19070-2 was associated with a significant improvement in symptoms in patients with IBS.1

Driving new research

To expand our knowledge on how our product concepts improve human health, we lead a program of clinical studies with strategic partners across the world. In addition to investigator driven or self-sponsored studies, we also partner with our customers on post marketing studies to continue collection of consumer experienced benefits. 

Please contact us if you are interested to discuss a possible collaboration!

Publications

The research articles listed here offer good insights into the proprietary probiotic strains of Biocare Copenhagen:

  1. The Effectiveness of Synbiotic Preparation Containing Lactobacillus and Bifidobacterium Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant Irritable Bowel Syndrome-A Randomized Double-Blind, Placebo-Controlled Study. Skrzydło-Radomańska B. et al., Nutrients. 2020 Jul 5;12(7):1999.
  2. Role of Lactobacillus rhamnosus (FloraActive) 19070-2 and Lactobacillus reuteri (FloraActive) 12246 in Infant Colic: A Randomized Dietary Study. Gerasimov S, et al., Nutrients. 2018 Dec 13;10(12):1975.
  3. Faecal Recovery, Mucosal Adhesion, Gastrointestinal Effects and Tolerance of Mixed Cultures of Potential Probiotic Lactobacilli. Rosenfeldt V. et al., Microbial Ecology in Health and Disease 2003; 5:  2 – 9.
  4. Effect of probiotics on gastrointestinal symptoms and small intestinal permeability in children with atopic dermatitis. Rosenfeldt V. et al., J Pediatr. 2004 Nov;145(5):612-6.
  5. Effect of probiotic Lactobacillus strains in children with atopic dermatitis.  Rosenfeldt V. et al., J Allergy Clin Immunol. 2003 Feb;111(2):389-95.
  6. Effect of probiotic Lactobacillus strains on acute diarrhea in a cohort of nonhospitalized children attending day-care centers. Rosenfeldt V. et al., Pediatr Infect Dis J. 2002 May;21(5):417-9.
  7. Effect of probiotic Lactobacillus strains in young children hospitalized with acute diarrhea. Rosenfeldt V. et al., Pediatr Infect Dis J. 2002 May;21(5):411-6.
  8. A comparative study on the use of flow cytometry and colony forming units for assessment of the antibacterial effect of bacteriocins. Budde BB, Rasch M., Int J Food Microbiol. 2001 Jan 22;63(1-2):65-72.
  9. Screening of probiotic activities of forty-seven strains of Lactobacillus spp. by in vitro techniques and evaluation of the colonization ability of five selected strains in humans. Jacobsen CN. et al., Appl Environ Microbiol. 1999 Nov;65(11):4949-56.

Microbial actives | Biocare Copenhagen

We focus on research and development of four natural and unique groups of microbial active ingredients targeting numerous indication areas

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